What are Regenerative Biologics?
1st Generation: PRP and PRFM
Platelet-Rich Plasma (PRP) and Platelet Rich Fibrin Matrix (PRFM) are distilled through a simple blood draw, where your platelets and fibrin are concentrated for use using a specially designed centrifuge. There is a long history of using PRP in orthopedics, dental surgery, and medical aesthetics. The components in PRP and PRFM help modulate cell proliferation, differentiation, chemotaxis, and angiogenesis. There is a wide body of evidence that shows PRP and PRFM help with accelerated healing and increased neo-collagenesis. PRP and PRFM contain numerous growth factors such as PDGF-AA, PDGF-AB, PDGF-BB, EGF, FGF, IGF-1, IL-1α, TGF-β1, VEGF.
2nd Generation: Amniotic Products
Amniotic products are derived from the amniotic membrane – commonly referred to as Amnion and Extracellular Matrix (ECM) – and amniotic fluid that are donated after the delivery of a healthy baby. They can contain as many as 250X the growth factors of PRP/PRFM. Amniotic products are anti-inflammatory by nature, therefore amniotic fluid helps reduce inflammation, increased epithelial cell reproduction, and increases angiogenesis. Amnion/ECM is particularly powerful in orthopedic and aesthetic applications due to the preponderance of growth factors and proteins organized and supported by a cellular matrix which serves to support the regeneration of healthy tissue.
3rd Generation: Autologous Stem Cells
Autologous Stem Cells are derived from your own body and come in 3 primary forms: SVF (Vascular Fraction), ADSC (Adipose-Derived Stem Cells), and BMAC (Bone Marrow Aspirate Stem Cells Concentrate). Obtaining these cells requires a relatively painful harvesting procedure such as tumescent liposuction or bone marrow aspiration which is then processed by mechanical processions such as microfiltration or enzymatic processing. These cells have demonstrated remarkable benefits for multiple clinical indications.
4th Generation: Mesenchymal Stem Cells (MSCs)
MSCs are multipotent stromal cells that can differentiate into a variety of cell types, come from the donated umbilical cords of healthy, full-term deliveries, and can be obtained in 2 different forms: Cord Blood or Wharton’s Jelly. Donated MSC’s derived from the umbilical cord after a live birth are more robust, younger, and contain a greater level of the growth factors and cytokines necessary for tissue regeneration than MSC’s from other sources. The applications of Cord Blood MSCs and Wharton’s Jelly MSCs vary dramatically as Wharton’s Jelly contains an even greater degree of cellular matrix and growth factors than Amnion/ECM.
5th Generation: MSC Exosomes
Exosomes were first discovered 30 years ago as a vesicle secreted by most cell types, but only in the last decade have we understood that their true purpose is the communication between neighboring and distant cells. Umbilical Cord MSCs can produce up to seven times more exosomes than adult MSCs, and because exosomes reflect properties of their source cells, will pass along their therapeutic attributes.
Do Regenerative Biologics work?
The efficacy of Regenerative Biologics depends greatly on a wide number of factors, and only after a consultation will our team be able to determine whether any of these options are right for your unique genetics, environment, and health.