Our Services: Peptide Therapy in Exeter, NH
WHAT ARE PEPTIDES?
Peptides are a type of pharmaceutical medications. They are defined as a sequence of amino acids less than 40 amino acids long. Peptides and proteins serve as the body’s natural signaling molecules similar to hormones. By mimicking the peptides found in the body or replacing them similar to hormone replacement therapy, you can affect disease and promote healthy lives in your patients. However, unlike small molecules and other medications, they have several advantageous properties which make them great in clinical practice!
THYMOSIN ALPHA-1: OPTIMIZE YOUR IMMUNE SYSTEM
Thymosin Alpha-1 (Tα1), a 28-amino acid peptide, was first described and characterized from calf thymuses in 1977. It is a peptide that can enhance T-cell, dendritic cell (DC) and antibody responses, modulate cytokines and chemokines production and block steroid-induced apoptosis of thymocytes. Due to its pleiotropic biological activities, Tα1 has gained increasing interest in recent years and has been used for the treatment of various diseases in clinics. Even recently, studies have shown that this peptide can reduce mortality from COVID-19 by 30% and even have an anti-aging.
Thymosin Alpha is one of the most widely applicable peptides available. It can be used for infectious diseases such as COVID-19, Hepatitis B and C, EBV, and many others. It can be used in autoimmune conditions such as rheumatoid arthritis, Hashimoto’s and others to reduce systemic inflammation. It has been studied and been given orphan drug status to help treat malignant melanoma and has positive data in most cancers. It even can help improve the immune system as we age and is a great resource for immunosenescence.
Thymosin Alpha-1 is a very pleiotropic peptide with many mechanisms of action. However, all of these actions work to help improve the immune system!
Bremelanotide PT-141 is now used to treat sexual dysfunction in men and women. Unlike other common medications such as Viagra and Cialis, this peptide works in the central nervous system to increase libido and arousal by stimulating certain parts of the brain.
Sexual function and performance is started in the brain. There are several neurochemical mediators which control the process, some increase libido and arousal while some decrease them. Bremelanotide PT-141 causes excitatory behavior in the paraventricular nucleus of the brain by stimulating Melanocortinin receptors. It is particularly helpful in women and has been FDA approved for women, however, it is also very effective in men at producing erections.
MELANOTAN I: SUNLESS TANNING & ANTI-INFLAMMATION
Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH) that induces skin tanning. Melanotan I plays a role in stimulating melanogenesis and thus provides a protective mechanism against UV rays since under its actions melanocytes are able to increase production and secretion of the hormone melanin. Melanotan I is an FDA approved drug under the brand name Scenesse. Scenesse is most commonly used to treat patients that have an intolerance to light.
OSTEOARTHRITIS, ALLERGIC RHINITIS, AND BACK PAIN
Pentosan polysulfate is a semi-synthetic polysulfated xylan used for the relief of Osteoarthritis. The mechanism of PPS action in osteoarthritis is multi-factorial, with both stimulation of cartilage matrix synthesis and prevention of cartilage breakdown. There are also systemic effects on blood lipid and fibrinolysis that may help clear the subchondral circulation. In one study, after a series of four to six intra-articular PPS injections into knees of human volunteers, there was a significant increase in the size of the synovial fluid hyaluronan without causing any inflammation or bleeding into the joint cavity.
This a great option for those patients that are suffering from osteoarthritis and are wanting to prevent surgery or intra-articular injections
Sermorelin is a synthetic hormone peptide composed of 29 amino acids. It’s similar in structure to a growth hormone releasing hormone (GHRH). It’s commonly utilized to optimize growth hormone levels in adults, while offering a variable IGF-1 increase. Sermorelin works to improve hormonal balance and enhance energy, burn
fat, increase lean muscle, improve sleep quality, enhance memory, sex drive and more by stimulating the production and release of hormones by the pituitary.
Semaglutide is a Glucagon-like peptide-1 (GLP-1) produced by the gut. It increases insulin production, a hormone that lowers the blood sugar level while inhibiting glucagon secretion, which is a hormone that raises blood sugar, and reduces appetite and energy intake while delaying gastric emptying. It was first developed in 2012 as a longer-acting option for Liraglutide. In 2017 this drug was approved as an anti-diabetic medication used to treat type 2 diabetes and obesity. In June 2021, it got approved for chronic weight management in obese individuals with a (BMI) ≥ 30 kg/m2) or overweight (initial BMI ≥ 27 kg/m2) with at least one weight-related comorbidity. L-Carnitine is an amino acid that benefits energy levels by transporting fatty acids into the mitochondria, where they can be burned up and used as fuel. For this reason, many take carnitine as a weight-loss supplement to help accelerate fat burning. L-Carnitine is an amino acid that benefits energy levels by transporting fatty acids into the mitochondria, where they can be burned up and used as fuel. For this reason, many take carnitine as a weight-loss supplement to help accelerate fat burning.
- Reduces food intake by lowering appetite
- It slows food digestion in the stomach
- Decrease body fat percentage
- Weight loss
- Decreased cardiovascular outcomes in subjects with type 2 diabetes and cardiovascular disease
- Lower HbA1c levels
- Enhance the growth of β cells in the pancreas
Insulin-like growth factor is a highly anabolic hormone that is released in the liver as well as in the peripheral tissues in response to the GH so that a new muscle could be built. The main work of IGF-1 is to build new muscle tissues by promoting nitrogen retention and protein synthesis. It differs from the original IGF-1 in that it possesses an arginine instead of a glutamic acid and also has an additional 13 amino acids. As a result, it is approximately three times more potent than IGF-1 and possesses a significantly longer half-life of about 20– 30 hours (comparative to IGF-1’s half-life of about 12–15 hours).
- Enhances muscle mass & strength
- Decreases inflammation & autoimmunity
- Improves gut health
- Boosts collagen production
- Helps balance insulin levels
- Stimulates weight loss
CJC1295 / Ipamorelin
CJC 1295 is a synthetically produced peptide that can increase your plasma growth hormone levels. Initially, CJC 1295 was developed to treat diseases and medical conditions for patients who had muscle disorders, diseases, and burn victims. CJC 1295 has drawn many individuals like athletes from around the globe for its incredible benefits and minimal side effects to enhance their performance on the field and in the gym. The primary purpose of CJC-1295 is to boost protein synthesis levels and help fuel the growth of muscle tissues in the body. Many benefits will be derived by users who are incorporating CJC-1295 to their regimen; among these are:
- Improve sleep quality
- Increase cognitive function
- Decrease body fat
- Quicker recovery times post-injury
- Increased muscle mass
- Increase in strength
Mitochondria play a vital role in cellular metabolism. Because of their widespread effects on cellular functions, mitochondrial dysfunction is implicated in a wide range of diseases. SS-31 has been shown to reverse mitochondrial dysfunction by obliterating damaging inflammatory agents such as free radical oxygen species (ROS).
SS-31 is very unique in its ability to cross the blood-brain barrier and highly concentrate within the inner membrane of the mitochondria (IMM). SS-31 shows promise in the treatment of many neurodegenerative and cognitive disorders such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, Friedreich ataxia, and glaucoma. Anti-aging research is investigating SS-31 for its ability to reverse mitochondrial dysfunction and premature cell death. The mitochondrial dysfunction theory of aging and the free radical theory of aging are intertwined and both would be addressed by the intracellular benefits of SS-31.
- Prevents Alzheimer’s Disease
- Prevents Glaucoma, Diabetes & Kidney Fibrosis
- Regenerates Skeletal Muscle Weakness
- Helps with Traumatic Brain Injury (TBI)
- Prevents Atherosclerosis & Heart Failure
Epitalon is a tetrapeptide composed of four amino acids (alanine, glutamic acid, aspartic acid, and glycine). It is a synthetic version of Epihalamine, a peptide extract of the pineal gland developed in Russia in the 1980s. In the early 2000s, excitement about Epitalon increased, even more, when scientists found it could activate telomerase, leading to the regrowth of telomeres.
Recent studies indicate that telomere length, which can be affected by various lifestyle factors, can affect the pace of aging and the onset of age-associated diseases. Telomere length shortens with age. The progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual. Shorter telomeres are associated with increased incidence of diseases and poor survival. The rate of telomere shortening can be either increased or decreased by specific lifestyle factors. Better choice of diet and activities has great potential to reduce the rate of telomere shortening or at least prevent excessive telomere attrition, leading to delayed onset of age-associated diseases and increased lifespan.
Epitalon has an important role, especially after 40 years, against aging not only by its action on the brain and pineal gland but also by increasing telomere length through its action as a telomerase activator.
Epitalon can provide you with better sleep and strengthen the immune system. Studies reveal increasing the cognitive capacities of your brain and bio-regulate your whole body through the action of the pineal gland and an increase in melatonin secretion. It has been intensively tested in Russia for more than 25 years and taken even by researchers for its anti-aging and enhancing properties. More people around the world increasingly use it.
- Increase in the life length by prolonging the telomeres in human cells
- Prevention of age-related declines & balance of melatonin production and circadian rhythm
- Normalized carbohydrate and fat metabolism
- Decreased rates of hypertension and cardiovascular disease
- Better management of metabolism and body weight & Improved endocrine health
- Reduced incidence of acute respiratory disease & Lower rates of osteoarthritis and osteoporosis
- Rehabilitation of nervous system activity & Repairs damaged and weakened muscle cells
- Improve physiological functions, and reduce mortality by almost 50% after 15 years
- Works as an antioxidant by reducing Lipid oxidation and ROS and normalizes T cell function
MK-677 is a hormone secretion compound that stimulates the pituitary gland to increase the production of human growth hormone. Ibutamoren is a long-acting, orally-active, selective, and non-peptide agonist of the ghrelin receptor and a growth hormone secretagogue, imitating the growth hormone (GH)-stimulating action of the endogenous hormone ghrelin. Increase IGF-1 Levels in as little as two weeks
- longer REM sleep and shorter sleep latency
- Increase fat-free muscle mass
- Decrease body fat percentage
- Stronger bones
- Improved endurance
- Increase nitrogen levels in the body
- Reversal of nitrogen wasting
MOTS-c is a peptide encoded as an sORF in the mtDNA that is metabolically and developmentally regulated, which has endocrine-like effects on muscle metabolism, insulin sensitivity, and weight regulation establishes its role as a member of a new class of mitochondrial signals which can be called MDPs (Lee et al., 2013). The MDP humanin similarly acts in a systemic fashion to protect neuronal and vascular systems from disease processes and toxic insults (Cohen, 2014; Lee et al., 2013). MOT-C is a short open reading frame (sORF) that encodes a signaling peptide inside the mitochondrial DNA (mtDNA). Mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation.
- Improves glucose regulation & decreases Insulin resistance
- Increases fatty acid oxidation & increases energy
- Promotes metabolic flexibility and homeostasis
- Protect against HFD-induced Obesity
DMAE / ESTRIOL / GHK-CU / HYALURONIC ACID BIOPEPTIDE CREAM
- Tightens loose skin, improves elasticity, reduces fine lines, and depth of wrinkles
- Reduces photodamage and hyperpigmentation
- Stimulates wound healing and reduces inflammation
- Reverses neurodegenerative diseases
- Facilitates formation of new functional synapses
- Hightens creative thinking
- Improves focus and learning